Tycho Brahe, a sixteenth-century Danish astronomer whose research helped Sir Isaac Newton devise the theory of gravity, died because he didn’t make it to the bathroom in time. In that society it was considered an insult to leave the table before the banquet was over. Brahe forgot to relieve himself before the banquet began, then exacerbated matters by imbibing too much alcohol at dinner. Too polite to ask to be excused, he instead allowed his bladder to burst, which killed him slowly and painfully over the next eleven days.
Experiment IV 